Synthesis, Table of Contents Synthesis 2020; 52(07): 1113-1121DOI: 10.1055/s-0039-1691575 paper © Georg Thieme Verlag Stuttgart · New YorkTransition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N-Propargyl Enamines Yuya Chikayuki , Takakane Miyashige , Shiori Yonekawa , Akiko Kirita , Natsuko Matsuo , Hiroyoshi Teramoto , Shigeru Sasaki , Kimio Higashiyama , Takayasu Yamauchi∗ Institute of Medicinal Chemistry, Hoshi University, Ebara, Shinagawa, Tokyo 142-8501, Japan Email: yamauchi@hoshi.ac.jp› Author AffiliationsRecommend Article Abstract Buy Article All articles of this category Abstract A transition-metal-free synthesis of pyridine derivatives by 6-endo-dig cyclization of N-propargyl enamines was developed. This method is environmentally friendly and is a high atom economy reaction that is easily accessed to provide pyridine derivatives in moderate to good yield by heating N-propargyl enamines in solvent without additives. 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